IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments
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چکیده
منابع مشابه
Human IL-21+IFN-γ+CD4+ T cells in nasal polyps are regulated by IL-12
In the previous study, we found that the levels of IL-21 in nasal polyps (NPs) were significantly increased and associated with polyp size and recurrence. However, it is unclear that the cell source of IL-21 and the regulation of IL-21 in NP tissues. In the present study, we isolated the lymphocytes from NP tissues, uncinate tissues and peripheral blood of patients with NPs. The cells were anal...
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IL-12p70 is an immunoregulatory cytokine that has been shown to induce IL-10 production from CD4+ T cells, yet the underlying cellular mechanisms controlling this process are poorly understood. In the present study, we demonstrate that IL-12p70 induces IL-10 production from human memory CD4+ T cells via a PI3K-dependent signaling mechanism. Specifically, stimulation of human memory CD4+ T cells...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2009
ISSN: 1521-6616
DOI: 10.1016/j.clim.2009.03.516